Friends. Friendos. Comrades. Take it from someone who has been here A Long Time: sometimes a pipe is just a pipe.
In context, Misha Collins is not talking about feeling useless because SPN is over. In context, he does not sound depressed, nor is he talking about mental health. IN CONTEXT he gave a non-answer to a question, either because he can’t put words in Cas’s mouth OR MORE LIKELY because the man literally cannot remember lines he said last week, forget almost a year ago. He is consistently the person who fails the “who said it” game. He’s probably apologizing and “feeling useless” because he cannot answer the question. And, honestly, probably because the DeanCas questions haven’t slowed down, and they haven’t become any less about us trying to reaffirm and prove their relationship existed in and is canon, and that probably, more than anything, has revealed to him the scale on which this show has fucked us. In a more abstract sense, I’d be willing to bet he’s apologizing for that too… because that is also something he can do absolutely nothing about.